• Title: Pedigree analysis in R
• Dates: July 28-30, 2021
• Where: Online, as part of ISFG Summer School 2021
• Teachers: Magnus Dehli Vigeland and Thore Egeland

## Description

The study of genetic relatedness and how genetic information flows in families, is central in a variety of research fields, including medical and forensic genetics. The aim of this course is to introduce the elegant statistical foundations of relatedness, as well as several forensic applications, with a particular focus on using R for calculations and visualisations. Most lectures and exercises are based on the book Pedigree Analysis in R. A 30% discount will be available for participants (but you do not have to buy the book in order to attend the course).

## Learning outcome

After completing the course the participants should have knowledge about:

• Classical concepts and methods of statistical genetics and relatedness analysis
• How to create, manipulate and plot pedigrees in R
• How to compute pedigree likelihoods and likelihood ratios in R
• How to perform kinship testing and pedigree reconstruction in R
• How to perform disaster victim identification in R

## Prerequisites

• Basic knowledge of genetics and probability.
• Some previous experience with R is recommended.
• Please make sure that R (version > 4.0) is installed on your computer. We recommend running R from RStudio.

The following R command installs the ped suite packages, which will be used throughout the course:

install.packages("pedsuite")

## Schedule

The course runs from 14 to 18 (CEST) each day, with a 15 minute break in the middle. The lectures are aimed at 55 minutes, allowing for a short interval before exercises.

#### Day 1 — July 28 (Wednesday)

• 14:00–15:00 Lecture 1. Introductions (MDV)
• 15:00–15:45 Exercise set 1
• 15:45–16:00 Break
• 16:00–17:00 Lecture 2. Working with pedigrees in R (MDV)
• 17:00–18:00 Exercise set 2

#### Day 2 — July 29 (Thursday)

• 14:00–15:00 Lecture 3. Kinship testing: paternity cases and complex cases (TE)
• 15:00–15:45 Exercise set 3
• 15:45–16:00 Break
• 16:00–17:00 Lecture 4. Relatedness coefficients (MDV)
• 17:00–18:00 Exercise set 4

#### Day 3 — July 30 (Friday)

• 14:00–15:00 Lecture 5. Relatedness inference and pedigree reconstruction (MDV)
• 15:00–15:45 Exercise set 5
• 15:45–16:00 Break
• 16:00–17:00 Lecture 6. Disaster victim identification and other forensic applications (TE)
• 17:00–18:00 Exercise set 6

Comments and questions may be sent to magnusdv at gmail dot com.